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the use of pro-GSH molecules (Fraternale et al., 2006) and/or glutathione precursors like N-acetyl cysteine (NAC), glutamine, cysteine (cystine) and glycine, as well as nuclear factor erythroid 2 p45related factor 2 (Nrf2) inducers like sulforaphane can enhance glutathione production and increase nuclear Nrf2 translocation and antioxidant response element (ARE) transcription (Komaravelli and Casola, 2014

Mitochondrial ROS overproduction has been indicated to donate to cardiomyocyte injury and greater myocardial injury after acute myocardial infarction (AMI) [9, 10]

Hepatic stellate cells (HSCs) are central drivers of liver fibrosis and cancer progression, differentiating into myofibroblasts and cancer-associated fibroblasts

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2-cyano-3,12 dioxoolean-1,9 diene-28-imidazolide induces apoptosis in pancreatic cancer via redox-dependent cytoplasmic stress