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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved
Napoli E, Wong S, Giulivi C
This subjective age reversal reflects objective improvements in hormonal signaling, tissue repair, and metabolic function that growth hormone optimization delivers
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10.1038/sj.ijo.0803344 111
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