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ACS Bio , 2025
Furthermore, the combined therapy was associated with better treatment adherence
Insufficient human clinical data Most research on AOD-9604 has been conducted in animals or short-term human trials, making it difficult to determine its full long-term effects
however, achieving complete insulin withdrawal is not common in patients treated with OWS
The lean-mass loss, which DEXA studies have now characterized in painful detail, runs at roughly 2540% of total weight lost, a number that is fine for the morbidly obese patient with surplus muscle to spare and quietly catastrophic for the older patient already trending toward sarcopenia
10.1073/pnas.100129497 364
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