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41 In a standard scenario, TMAO levels are affected by numerous factors such as diet, underlying diseases, lifestyles, and basic studies have found that TMAO may also be the causative agent of certain other cardiovascular diseases and neurological diseases, and these covariates may mask the authentic relationship between TMAO and AF as well as arrhythmia

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Allocation concealment mechanism The statistical consultant of the project provided a random allocation sequence for assignment of the patients into the case and control groups