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Risk of lactic acidosis increases in patients with kidney disease, liver disease, or excessive alcohol use

Several natural compounds have been proposed as interventions for PD including coenzyme Q10, curcumin, resveratrol and omega-3 fatty acids, however these agents have shown limited clinical efficacy, often failing to produce measurable changes in Unified Parkinsons Disease Rating Scale (UPDRS) outcomes or biomarkers of oxidative stress

Multi-dose pens require the date of first use to be written on the label