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The bigger risk is extended time out of the fridge or exposure to heat sources

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The effects of extended bedtimes on sleep duration and food desire in overweight young adults: A home-based intervention., Appetite, PMID: 24858836

It is critical to emphasise that dedicated cardiovascular outcomes trials (CVOTs) the gold standard for assessing a drug's long-term effect on events such as heart attack and stroke have not yet been completed for retatrutide

It happens because Semaglutide mimics a hormone called GLP-1 (glucagon-like peptide-1), which helps regulate appetite and slows digestion in the first week or two