Each one is briefly summarized below as it appears in published in-vitro and pre-clinical work not as a therapeutic claim
Lancet (1975) 1(7897):146
It is an active part of the immune system
Epidemiological data on suicide reveals that the 12-month prevalence of suicidal ideation is greater in females than males whereas the prevalence of suicide attempts is comparable for females and males [Reference Borges, Nock, Haro Abad, Hwang, Sampson and Alonso36]
While acute cortisol increases may be tolerable, protocols involving frequent or long-term administration would ideally avoid this confound
In a murine GL261 glioblastoma, a model NIC treatment resulted in a notable increase in cytotoxic CD8 + T cells, natural killer (NK) cells, and macrophages, along with a reduction in regulatory Tregs within the TME