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Deletion of hepatocyte-specific DPP4 in these aged mice did not affect glucose tolerance as only whole-body deletion of DPP4 increased systemic active GLP-1 and led to reduced blood glucose excursion during oral glucose tolerance test (Supplemental Figure 3, A and B), consistent with previous work (22, 23)

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The maximum discharge current can be calculated using: Current (A) = Battery capacity (Ah) C rating A higher C rating provides higher power output but may increase cost, size, and heat generation

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The rationale for combining these two peptides is rooted in their complementary mechanisms of action