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10.1038/nature15726 46 PranziniE.PardellaE.MuccilloL.LeoA.NesiI.SantiA.et al (2022)

On the other hand, the buffering function of IGFBPs, which normally prevents supraphysiologic receptor saturation, is absent

This means they trigger your body to release its own growth hormone

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S3 A ), consistent with our prior findings in cell lines (16)

With GLP-1 receptor agonists (GLP-1 RAs) , we now have a tool that can accelerate weight loss and glycemic control more effectively than ever before producing 518% body-weight reduction in clinical trials ( Endocrinology Advisor )