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Secondary endpoints included the proportion of participants achieving at least 10, 15, 20, and 25 percent weight loss, change in waist circumference, and improvement in cardiometabolic risk factors such as blood pressure and lipid profiles
Continued scrutiny of drug pricing appears likely, particularly given the rapidly evolving and uncertain US drug pricing environment, adding uncertainty for the companies set to enter the GLP-1 space
Mechanism Difference: Tirzepatide (Zepbound/Mounjaro): Dual GIP/GLP-1 receptor agonist Semaglutide (Wegovy/Ozempic): GLP-1 receptor agonist only Published Clinical Trial Data (Separate Studies): Tirzepatide (SURMOUNT-1): 16.0% to 22.5% mean weight loss at 72 weeks depending on dose Semaglutide (STEP trials): Approximately 15% mean weight loss at 68 weeks These trials were conducted separately with different patient populations and protocols
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