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Contraindications include known hypersensitivity to mannitol (present in the formulation), active malignancy, pregnancy, disruption of the hypothalamic-pituitary axis (after surgery, radiation or major trauma), and severe hypersensitivity to any component of the lyophilized product

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Giustarini D, Tsikas D, Colombo G, Milzani A, Dalle-Donne I, Fanti P, et al

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