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It oxidizes into glutathione disulfide (GSSG), where the SS denotes the disulfide bond between two glutathiones
Xenobiotics containing a carboxyl group (COOH) are widely used as drugs (for example simvastatin, valproic acid, or acetylsalicylic acid), herbicides, insecticides, and food preservatives
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were the first to encounter CHAC1 expression in the context of cancer cell death ( CHAC1 gene is highly upregulated in HNSC cancer after treatment with nisin which was then followed by cell death ( CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues ( CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed (Wang et al., 2019)
Erratum in: CNS Drugs
It regulates the natural defense system and supports the liver and gallbladder in fat metabolism
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