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Semaglutide 2.4 mg (Wegovy) produced an average 15 % weight reduction at 68 weeks in the STEP-1 trial.[pmc.ncbi.nlm.nih.gov] Tirzepatide 15 mg (Zepbound) delivered up to 22 % weight loss at 72 weekscurrently the largest seen with an approved injectable
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Precision psychiatry: a neural circuit taxonomy for depression and anxiety
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While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
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