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The concerns are formulation-level: copper ions can potentially destabilize some retinoid formulations, and layering both in one application step can increase irritation risk in sensitive users

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Maybe not dramatically

Both zymosan and GlcC14C18 exacerbated SCI-NHO development (Fig

Urine steroids may be considered a more time integrated measure of steroid exposure, production and excretion which may buffer out fluctuations evident in serum steroid concentrations