In the US, the Food and Drug Administration (FDA) has warned that some patients are turning to unapproved versions of GLP-1 drugs, including semaglutide and tirzepatide, for weight loss
Additionally, some patients may experience muscle cramps or discomfort as a side effect of changes in hydration or mineral levels, which can be affected by gastrointestinal symptoms like diarrhea
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In this context, the cost of not treating obesity and adipose tissue dysfunction at early stagesthus enabling the progression to complications and end-organ damageshould be weighed equally in health policy and clinical decision-making, the authors said
doi:10.2337/diabetes.54.8.2375 39
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