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The co-dissolved drug is trapped during the gel process and its much less likely that the drug will be washed out. In other words, the drug can be injected directly into the desired area and it will stay there, doing its work without affecting other parts of the body

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It is characterized by painful intraepidermal vesicles, erosion, maceration, and frequent secondary infections, primarily in the flexural areas

n=17) at 6 months

Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women. Ann Intern Med