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Although we cannot rule out a contribution of glycolysis to this ATP increase and did not directly assess the activity of other complexes, we observed increased 5FU sensitivity with inhibitors of ETC complexes IIV, genetic ablation of CI and CIV, and sensitizer genes from CRISPR screening covering additional complexes (CIII and CV)

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Because it works through the natural signaling pathway, the negative feedback loop stays intact: somatostatin and IGF-1 can continue to regulate the output

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Unlike most growth-factor-promoting compounds, BPC-157 has not demonstrated tumor-promoting activity in any published study