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Wenwen Cheng, Ermelinda Ndoka, Chelsea Hutch, Karen Roelofs, Andrew MacKinnon, Basma Khoury, Jack Magrisso, Ki Suk Kim, Christopher J

Long-term success is much more likely when nutrition habits and strength training are already in place

Patients losing over 75 pounds with tirzepatide almost always develop some excess skin, while those losing 30-40 pounds may see minimal looseness that improves with time and exercise

But there are significantly fewer diabetes-related deaths now, so the medicine side of the equation has all but been resolved and thank goodness for that

Low oral doses (3 mg, 7 mg, or even 14 mg) have shown minimal weight loss benefit, which is why patients on lower-dose oral forms often see disappointing results

It was shown that GLP-1 enhances glycogen synthesis and glucose transport by affecting various pathways (2426)