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The hormone glucagon-like peptide 1 (GLP-1) is released to help stimulate the production of insulin and the uptake of glucose in muscle and other tissues

Importantly, surgery also alters incretin signaling itself, increasing GLP-1 activity and improving insulin sensitivity in ways that complement pharmacologic therapies

Importantly, renal and hepatic impairment do not meaningfully alter tirzepatide pharmacokinetics, and no dose adjustments are required for patients with kidney or liver disease

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