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Conversely, lactate promotes M2-polarization of tumor-associated macrophages (TAMs) (17) and myeloid-derived suppressor cells (MDSCs), while stimulating their secretion of immunosuppressive mediators, such as vascular endothelial growth factor (VEGF), interleukin (IL)-10, and accelerating programmed deathligand 1 (PD-L1) expression (18)

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For best results, it can be taken after a meal consisting of the following dosage