Furthermore, the contribution of melatonin in relation to modulating the symptoms of PCOS through its involvement with the regulation of appetite and metabolic processes highlights the importance of this part of treatment [188]
Cell Reports, 28, 2608-2619.e6
Anabolic effects of insulin-like growth factor-I (IGF-I) and an IGF-I variant in normal female rats
The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months
On the question of raw, proven efficacy for photoaging, the honest answer is that tretinoin has the stronger evidence base but the picture is more nuanced than a simple winner-takes-all verdict
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