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it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 50,51,52

Neither is magic

Briefly, we grew HepG2 on 12 mm coverslips until 70% confluence, starved them, and then treated them with OA and Ex-4 as needed

Remington, R., Chan, A., Paskavitz, J., and Shea, T