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The SURMOUNT-1 trial (Jastreboff et al., NEJM , 2022) showed tirzepatide at its highest dose produced average weight loss of over 22% of body weight, compared to roughly 15% for semaglutide at maximum dose in the STEP 1 trial

they are sudden food aversions driven by complex neurobiology

Discount is calculated by comparing the 12-month upfront purchase price to the standard monthly price of $299 (pill) or $349 (injectable) or $399 (7.2 mg injectable)

Why This GLP-1 Pill Matters Many people want a GLP-1 weight-loss pill because: It avoids injections It may improve long-term treatment adherence It offers a daily routine instead of a weekly dose It could make weight-loss care more accessible This is why orforglipron is being discussed as a major contender in the GLP-1 pill vs injection debate

Knudsen: Its true that over the years Ive clashed with some colleagues who focus on insulin

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