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Ongoing research is probing novel applications of GLP-1 agonists beyond diabetes and obesity from potential use in metabolic dysfunction-associated steatohepatitis (MASH) to trials investigating neuroprotective effects in conditions like Parkinsons and Alzheimers disease, though the 2025 phase 3 trials in both conditions failed to show clinical benefit ( [24] ) ( [25] )
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In terms of receptor affinity and long-term effectiveness, GLP-1 RAs activate GLP-1 receptors more effectively and for longer periods of time than native GLP-1, resulting in therapeutic benefits that last longer (Zheng et al
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An abscisic acid-induced protein, HVA22, inhibits gibberellin-mediated programmed cell death in cereal aleurone cells
Thus, enriched G- in patients with GER symptoms may induce esophageal barrier dysfunction via the LPS-TLR2-IL-6-claudin-1-DIS pathway (48)
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