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At the peak of the shortage in 2024, nearly one in three Americans on a GLP-1 drug reported getting it from a compounding pharmacy
A qualified assessmentpotentially including biomarker and genetic contextinforms this decision
Biological Psychiatry, 61(9), 10451052
10.1016/j.eplepsyres.2023.107190 16 CovolanL.SmithR.MelloL
As GLP-1 RAs ripple into adjacent sectors, from brain health to renal disease, competition is heating up, and the appetite for next-generation therapies is growing
1 Tirzepatide 15 mg: -11.2 kg average weight loss Injectable semaglutide 1 mg: -5.7 kg average weight loss HbA1c: -2.30% with tirzepatide 15 mg vs -1.86% with semaglutide 1 mg Rybelsus 14 mg (the highest available oral dose) produces roughly equivalent blood levels to injectable semaglutide 0.5-1.0 mg per week, which is at or below the injectable dose tested in SURPASS-2
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