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pro-apoptotic pathways, including the activation of caspases and prolonged c-Jun NH2 terminal kinase (JNK) signaling, are antagonized by various NF-B target genes 28

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Specifically, on the extracellular side, -, - and -sarcoglycans co-fold to form a specialized, extracellular tower-like structure, which has a central role in complex assembly by providing binding sites for -sarcoglycan and dystroglycan