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Gene Expression ECM Remodeling Copper Signaling Mechanism of Action Primary TGF- / Collagen / LOX Extracellular Matrix Remodeling GHK-Cu upregulates collagen I, collagen III, and decorin synthesis in fibroblast cultures

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Together, this suggests that altered PfK13 modulates the levels of reduced GSH, leading to a more reducing cellular environment in artemisinin-resistant parasites

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CHAC2a is constitutively expressed, whereas CHAC2b exhibits higher catalytic activity and is induced during sulfur starvation, suggesting a specialized role in nutrient stress response ( 4.1 CHAC enzymes in plants In plants, GSH plays a vital role in mediating biotic stress ( Consequently, the current understanding of glutathione-degrading enzymes in plants remains limited