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Conclusion In summary, the results of this population based study, designed to closely emulate a randomised controlled trial, suggest that the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination is associated with a lower risk of major adverse cardiovascular events and serious renal events among patients with type 2 diabetes compared with each drug class alone
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8 The medications may lead to high volumes of complex gastric contents despite appropriate fasting per ASA practice guidelines for preoperative fasting
Effectiveness The SCALE Obesity and Prediabetes trial found 4 : 8.0% average weight loss with Saxenda vs 2.6% with placebo 63.2% of participants lost at least 5% of their body weight 33.1% lost at least 10% These results are meaningful but significantly lower than both Mounjaro and Wegovy
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