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5.2 Paradoxical psychiatric effects and safety considerations A critical pharmacological consideration in the use of biological therapies is the emergence of paradoxical psychiatric adverse events (PAEs)

doi: 10.1016/S0140-6736(18)32261-X 37 HomePDShamannaPStewartMYangFMillerMPerryCet al

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[2] [11] [12] [13] Diarrhea is a common adverse reaction associated with tramadol use

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