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[PubMed Central ID: PMC4731948]

It works by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

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This allows for a greater overall therapeutic window and contributes to the unprecedented efficacy observed in clinical trials

They typically result in more weight loss than any other medication currently available and, in some cases, reach the level of weight loss seen with metabolic (bariatric) surgery