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Thus, observed potent induction of ferroptosis, GPX4-dependent novel suppression of mTOR pathway and DNA damage repair response in preclinical in vitro model of TC supports GPX4 targeting for therapeutic benefit in advanced therapy-resistant thyroid cancers
A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair
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The control group exhibited a significantly lower apoptotic ratio compared to the IL-6 and TNF- applied cells but higher than NAC applied cells (Fig
That matters because the two compounds work through completely different pathways, and the safety data we have on AOD-9604 alone is already thin