and AUC for digoxin 0120 h after a single dose of digoxin
The most frequent gastrointestinal side effects include: Nausea and vomiting : Very common, typically most pronounced during dose escalation Diarrhoea : Common to very common, though usually mild to moderate Constipation : Can occur due to delayed gastric emptying and reduced gut motility Abdominal pain and discomfort : Common Dyspepsia and gastro-oesophageal reflux : May worsen in susceptible individuals Other important adverse effects include: Gallbladder disorders : Cholelithiasis and cholecystitis have been reported, particularly with weight loss Dehydration and acute kidney injury : May occur secondary to severe gastrointestinal symptoms Hypoglycaemia : Risk increases when used with insulin or sulfonylureas, which may require dose adjustment Current limited evidence does not suggest an increased risk of inflammatory bowel disease (IBD) flares with GLP-1 agonists, though more data are needed
Approved UK alternatives include semaglutide (Wegovy) and orlistat, accessible through a GP or specialist weight management service
Yes, when taken within recommended dosages, oral glutathione is generally safe
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62% (tirzepatide) vs 37% (semaglutide) achieved 10% or greater weight loss and 42% (tirzepatide) vs 18% (semaglutide) achieved 15% or greater weight loss within a year
