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The injection can cause prostatic abscess and sepsis, although this is rare.25 Nevertheless, high fever and postprocedural pain should be carefully evaluated
Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]
July 15 (Reuters) - Novo Nordisk said on Wednesday the European Commission approved its once-daily Wegovy pill for weight management in adults with obesity or who are overweight, making it the first oral GLP-1 weight-loss treatment cleared for use across the European Union
However, growth hormone can transiently increase fasting glucose in insulin-resistant individuals, potentially offsetting some of semaglutide's metabolic benefits
Other important safety considerations include injection site reactions, increased heart rate (a class effect, though potentially more pronounced with liraglutide), and risk of pancreatitis (which requires immediate discontinuation if suspected)
7 GLP-1RA effects that may be important in patients with HFpEF include glycaemic control, weight loss, reductions in epicardial fat and blood pressure (BP), alleviation of atherogenesis and systemic inflammation and improvement of endothelial function
