Clinically, the treatment strategies during phase I utilize conventional methods: patients should be treated with hypothermia, free radical scavengers (e.g., melatonin, erythropoietin, coenzyme Q10), excitatory amino acid receptor blocking agents, and/or neuroprotective agents
Additionally, NRC-03 and NRC-07, two AMPs from the pleurocidins AMP family, exhibited equal killing effect at a concentration of 50M on normal MCF7 cells and on paclitaxel-resistant breast cancer cell line MCF7-TX400 that possess 2.6 times of P-gp expression more than the normal MCF7 cells, achieving about 60% of cell killing rate
The assessment of ototoxicity is necessary for medications delivered via the otic route that are anticipated to affect the middle or inner ear during clinical application (Pasdelou et al
However, over time, if not sealed properly, it can absorb dust, bacteria, or chemicals from the air, potentially affecting its quality
Perfect For: Anyone looking to reduce dark circles, puffiness, or fine lines
Others simply stop the treatment altogether
