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[5] proved that GIP, originally named gastric inhibitory polypeptide, could explain this incretin effect by inducing glucose-stimulated insulin secretion, and renamed the peptide as glucose-dependent insulinotropic polypeptide. Following the identification of GIP, the search for insulinotropic incretins persevered

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certain medications including corticosteroids, antipsychotics (such as olanzapine, quetiapine), and some antidepressants (particularly mirtazapine) can increase appetite and potentially diminish semaglutide's effects

LZ: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Writing original draft

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Acyl-CoA then enters -oxidation: acyl-CoA dehydrogenase catalyzes the conversion of acyl-CoA to trans-delta 2 -enoyl-CoA