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The results were significant: At 48 weeks, participants receiving the 12 mg dose achieved a mean weight reduction of 24.2% (approximately 58 pounds or 26.2 kg) 100% of participants on the 8 mg or 12 mg doses lost at least 5% of their body weight More than 90% of participants on the 12 mg dose lost at least 10% of their body weight Nearly half of participants on the highest dose lost 25% or more of their body weight The study also showed improvements in cardiometabolic markers including blood pressure, triglycerides, LDL cholesterol, and fasting glucose

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ORR at the end of cycle 16 served as the trial's primary end point

This article covers the receptor biology each peptide targets, how clinical trial data reflects those differences, and what those mechanisms mean for research applications focused on metabolic disease, obesity, and NASH