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Start: 2 mg weekly for 4 weeks to assess tolerance [6]
Weight changes (if they happen) typically track with the overall program and consistency rather than the injection alone
Compared with LIR once a day, once weekly subcutaneous injection of DUL similarly lowers body weight: 2.90 kg (-3.61 kg for LIR) after 26 weeks of treatment (109)
However, past pancreatitis is not a contraindication for these agents, and contrary to the previous warning, recent studies have not shown an increased pancreatic risk associated with GLP-1 RAs, leading to ongoing revisions in treatment guidelines
The data Sustained loss, month after month