References: Mercury and protein thiols: Stimulation of mitochondrial F1FO-ATPase and inhibition of respiration Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA Mercury has an affinity for the brain References: The Toxicology of Mercury and Its Chemical Compounds (Clarkson, Thomas, Magos, Laszlo, 2006) (a rather complete introduction to mercury toxicity) "The concentration in brain is about 5 times than in scalp hair about 250 times the corresponding concentration in blood" "Animal data including primates indicate that brain levels in the newborn may be as high as five times the corresponding levels in the mother" "Experimental work on rats has shown that methylmercury gains entry into the endothelial cells of the bloodbrain barrier as a complex with cysteine (Kerper et al., 1992
A small percentage dont respond well at all
CoQ10 (100 to 300 mg daily) supports mitochondrial energy metabolism relevant to migraine prevention
The medications themselves (compounded semaglutide and tirzepatide) are the same molecules studied in STEP 1 and SURMOUNT-1
GRAS food ingredient note AOD-9604 was self-affirmed as Generally Recognized As Safe (GRAS) by an industry expert panel for limited food-ingredient use based on the Phase 1 and Phase 2 safety data
By the end of this article, youll have a comprehensive understanding of these medications, their mechanisms, and factors to consider if youre thinking about incorporating them into your weight loss journey
