exendin-4 vs semaglutide Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists Semaglutide vs. Other GLP-1 Receptor

So glad I have been familiar with Nrf2 activation for over 8 yrs now

Studies using chick embryo chorioallantoic membrane (CAM) assays and human umbilical vein endothelial cells (HUVECs) have demonstrated BPC-157's capacity to increase blood vessel production and tube formation significantly, with observed increases of 129-152% in CAM assays and 119-147% in HUVECs at optimal concentrations

Neurotox Res 2022:127 Wu H et al (2022) Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism disease model

While metformin does cross the placenta, multiple studies and meta-analyses have not demonstrated increased risks of major congenital malformations compared to insulin therapy

Kopecek J: Smart and genetically engineered biomaterials and drug delivery systems

10.1186/s40164-023-00410-5 499 YinJ.LiaoS.-X.HeY.WangS.XiaG.-H.LiuF.-T.et al