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The difference is the FDA-approved indication

The therapy uses a very small, fine needle, similar to what's used for insulin, and the injection goes just under the skin into fatty tissue

The shortage led to an increased demand for off-brand versions

Through September 30, 2026 , most standard Aetna commercial plans still exclude Zepbound, and your options are: (1) check if you have a self-funded employer plan your HR department may have kept coverage

In clinical trials , Mounjaro users achieved significant weight loss, averaging around 18.4%, with some even losing up to 25.3%

"Lilly was the first company to offer a self-pay solution for an FDA-approved obesity medication, and we continue to work to expand coverage for Zepbound