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if a substance is injected too quickly, that can also cause more pain because of the sudden presence of the medication

Pegoretti V, Swanson KA, Bethea JR et al (2020) Inflammation and oxidative stress in multiple sclerosis: consequences for therapy development

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49 There are now several trials in the literature documenting a positive role of orally administered glutathione for the treatment of hyperpigmentation, despite its poor absorption