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Endocrinology 136 , 35853596 (1995)

Origin: Mainland China

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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

3.1 MQC dysfunction may contribute to impaired ECM synthesis-degradation homeostasis A key pathological consequence of MQC dysfunction may involve the impairment of ECM synthesis-degradation homeostasis in chondrocytes, a process that appears to be linked to the aberrant activation of ROS-mediated signaling pathways (38, 39)