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The most common side effect is stomach discomfort (typically in the form of bloating), especially during a loading phase, where people take 20-25 grams daily

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(14) These emerging connections between GLP-1 signaling and skeletal physiology present a biologic rationale for how GLP-1 receptor agonists have potential to not only assist in weight management, but also favorably influence bone health and remodeling

Some lean mass can be lost during any type of weight loss, especially when calories or protein are too low

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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [19]