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Indeed, osteoblastic cell lines express GLP-1 receptors (53), and GLP-1 receptor knockout mice exhibited increased bone resorption and cortical osteopenia (54)
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Monitor closely for known tirzepatide side effects (GI intolerance, pancreatitis risk, etc.)
This could manifest as reduced anxiety symptoms, though such effects would likely be indirect rather than a direct pharmacological action on anxiety pathways
tirzepatide targets two (GLP-1 and GIP), which is one reason it tends to produce stronger appetite suppression for many people
The GLP-1 prescription requirements are based on clinical guidelines established by medical organizations and FDA approval criteria
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