Though systematic absorption of topically applied retinoids, such as retinol and tretinoin, is low, doctors recommend avoiding them while pregnant and nursing
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Another observation from studies on murine models exposed to catabolic agents revealed a reduction in the excretion of N-methylhistidine, a marker of muscle protein degradation, which was notably more pronounced with IGF-1 LR3potentially three times greater than with IGF-I
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Lower myostatin = greater potential for hypertrophy