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We hypothesized that individuals who are using GLP-1 RAs would have lower odds of developing SUDs compared to non-users

Common requirements include documented BMI meeting the threshold, proof of previous weight loss attempts (usually 3-6 months of supervised diet and exercise), at least one qualifying comorbidity, and sometimes evidence that other treatments have been tried and failed

No single approach is likely to be enough

Overall, the MIA mice had significant improvement of sociability while receiving the MT-II infusion and this is the first study to our knowledge to explore chronic administration of melanocortin 4 receptor agonist on social behaviors

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