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Distinct from the above pathways, the alternative pathway of NLRP3 inflammasome activation bypasses pyroptosis, ASC polymerization, and K + efflux, which has been exclusively characterized in primary human and porcine monocytes

These may include a history of pancreatitis, current pregnancy, or rare conditions such as certain types of thyroid cancer

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The Phase 2 trial tested four dose levels, and the dose-response curve was remarkably linear