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Bigarella CL, Liang R, Ghaffari S

Furthermore, these pathways have also been linked to appetite regulation, modulation of gastric emptying, and cardiovascular effects ( Semaglutide and liraglutide effects on central nervous system regulation GLP-1 and GLP-1RA are involved in the activation of various central nervous system (CNS) processes, including satiety, thermogenesis, blood pressure, neurogenesis, and inflammation reduction ( Obesity has been associated with chronic inflammation, and GLP-1RA can modulate these inflammatory processes ( Moreover, GLP-1 promotes neurogenesis by reducing inflammation and decreasing the expression of proinflammatory cytokines IL-6, IL-10, and microglial activation ( Studies have observed that GLP-1RA decreases food intake, slows gastric emptying, and promotes the release of hormones such as leptin and peptide YY, involved in satiety ( Metabolic effects Semaglutide and liraglutide on insulin secretion The effect of GLP-1 and GLP-1RA in pancreatic -cells promotes glucose catabolism and insulin secretion ( Semaglutide, liraglutide and glucose homeostasis Liraglutide and semaglutide are mainly prescribed for the treatment of DM2 ( Lipid metabolism Semaglutide and Liraglutide effects on lipid metabolism GLP-1RA drugs have been associated with reduced food intake and body weight loss ( de novo lipogenesis

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Schiavon CA, Bersch-Ferreira AC, Santucci EV, Oliveira JD, Torreglosa CR, Bueno PT, et al

Medications such as testosterone and peptidesa largely untested class of drugs with a wide range of purported health benefitsare in high demand too

Disadvantages of using oral forms: inferior absorption, inferior cellular activity, require high compliance with daily dosing