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GHRH upregulates the pituitary-specific POU homeodomain transcription factor, Pit-1, which in turn, transcriptionally upregulates the GH1 , GHRHR and Pit-1 genes (auto-upregulation)
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In patients with T2DM and hepatic steatosis, Cuthbertson et al
contributed to the final writing of the paper
No pharmacokinetic conflict is known
First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism
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