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The availability of substrates and especially FAs to mitochondria serves as a limiting factor for mitochondrial function in energy production 15,16
Glutathione is involved in regulating the genes and the production of cytokines that cause chronic inflammation
We noticed that Klotho deficiency and aging decreased expression of TRXR1 (thioredoxin reductase), an enzyme known to catalyze the reduction of thioredoxin, 54 in cardiomyocytes (Online Figure XVID and XVIJ and Online Figure XVIID and XVIIJ)
In fact, therapeutic doses of metformin (150 M) protect endothelial function by interacting with the orphan nuclear receptor Nur77/NR4A1 to reduce hyperglycaemic-induced ROS [113]
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